Cimetidine
400 mg BD or 800 mg OD at bed time,
50 mg/hour i.v. infusion;
CIMETIDINE, 200 mg, 400 mg, 800 mg tabs, 200 mg/2 ml inj.
Ranitidine
For ulcer healing – 150 mg BD or 300 mg at bed time;
For prevention of ulcer recurrence –150 mg at bed time;
For Zollinger-Ellison syndrome – 300 mg TDS or QID; Parenteral dose 50 mg i.m. or slow i.v. injection every 6–8 hours or 0.1–0.25 mg/kg/hr i.v. infusion;
ULTAC, ZINETAC 150 mg, 300 mg tabs;
HISTAC, RANTAC, RANITIN, ACILOC 150 mg, 300 mg tabs, 50 mg/2 ml inj.
Famotidine
40 mg at bed time or 20 mg BD (for healing); 20 mg at bed time for maintenance; upto 480 mg/
day in ZE syndrome; parenteral dose 20 mg i.v. 12 hourly, or 2 mg/hr i.v. infusion.
FAMTAC, FAMONITE, TOPCID 20 mg, 40 mg tabs; FAMOCID, FACID 20, 40 mg tabs, 20 mg/2 ml inj.
Roxatidine
150 mg at bed time or 75 mg BD; maintenance 75 mg at bed time.
ROTANE, ZORPEX 75 mg, 150 mg SR tabs.
Omeprazole
20–60 mg/day, ZE syndrome 60–120 mg/day in two divided doses; OMIZAC, NILSEC 20 mg
cap. OMEZ, OCID, OMEZOL 10, 20 mg caps, PROTOLOC 20, 40 mg caps containing enteric coated granules.
Capsules must not be opened or chewed; to be taken in the morning before meals.
Esomeprazole (s-omeprazole):
20–40 mg OD; NEXPRO, RACIPER, IZRA 20, 40 mg tab.
Lansoprazole
Ulcer healing dose:
15–30 mg OD; LANZOL, LANZAP, LEVANT, LANPRO 15, 30 mg caps.
Pantoprazole
40 mg OD; PANTOCID, PANTODAC 20, 40 mg enteric coated tab; PANTIUM, PANTIN
40 mg tab, 40 mg inj for i.v. use.
S(-) Pantoprazole:
20 mg OD; PANPURE, ZOSECTA 20 mg tab.
Rabeprazole
20 mg OD, ZE syndrome 60 mg/day;
RABLET, RAZO, RABLOC, RABICIP, HAPPI 10, 20 mg tab, 20 mg/ml vial for inj.
Dexrabeprazole
10–20 mg OD; DEXPURE, 5, 10 mg tabs.
Misoprostol (Methyl PGE1 ester)
200 µg QID; CYTOLOG 200 µg tab; MISOPROST 100 µg, 200 µg tabs.
Magnesium hydroxide
0.4–1.0 g as often as required; MILK OF MAGNESIA 0.4 g/5 ml suspension.
Aluminium hydroxide gel
0.6–2.4 g as required; ALUDROX 0.84 g tab, 0.6 g/10 ml suspension.
Magaldrate
0.4–0.8 g as required; STACID 400 mg tab, 400 mg/5 ml susp;
ULGEL 400 mg with 20 mg simethicone per tab or 5 ml susp.
Combination antacid preparations
ACIDIN:
Mag. carb. 165 mg, dried alum. hydrox. gel 232 mg, cal. carb. 165 mg, sod. bicarb. 82 mg, with kaolin
105 mg and belladonna herb 30 µg per tab.
ALMACARB:
Dried alum. hydrox. gel 325 mg, mag. carb. 50 mg, methyl polysilox. 40 mg, deglycyrrhizinated
liquorice 380 mg per tab.
ALLUJEL-DF:
Dried alum. hydrox. gel 400 mg, mag. hydrox. 400 mg, methyl polysilox. 30 mg per 10 ml susp.
DIGENE:
Dried alum. hydrox. gel 300 mg, mag. alum. silicate 50 mg, mag. hydrox. 25 mg, methylpolysilox.
10 mg per tab.
DIGENE GEL:
Mag. hydrox. 185 mg, alum. hydrox. gel 830 mg, sod. carboxymethyl cellulose 100 mg, methyl-
polysilox. 25 mg per 10 ml susp.
GELUSIL:
Dried alum. hydrox. gel 250 mg, mag. trisilicate 500 mg per tab.
GELUSIL LIQUID:
Mag. trisilicate 625 mg, alum. hydrox. gel 312 mg per 5 ml susp.
MUCAINE:
Alum. hydrox. 290 mg, mag. hydrox. 98 mg, oxethazaine 10 mg per 5 ml susp.
TRICAINE-MPS:
Alum. hydrox. gel 300 mg, mag. hydrox. 150 mg, oxethazaine 10 mg, simethicone 10 mg per
5 ml gel.
MAYLOX:
Dried alum. hydrox. gel 225 mg, mag. hydrox. 200 mg, dimethicone 50 mg per tab and 5 ml susp.
POLYCROL FORTE GEL:
Mag. hydrox. 100 mg, dried alum. hydrox. gel 425 mg, methylpolysilox. 125 mg per
5 ml susp.
Sucralfate
Ulcer healing dose:
1 g taken 1 hour before 3 major meals and at bed time; To prevent recurrences
1 g BD; SUCRACE, ULCERFATE, RECULFATE 1 g tab.
Colloidal bismuth subcitrate (CBS, Tripotassium dicitrato-bismuthate)
120 mg (as Bi2O3) taken
30 min before 3 major meals and at bed time; TRYMO, DENOL 120 mg tab.
Anti-H. pylori antimicrobials
Amoxicillin:
750–1000 mg BD
Clarithromycin:
500 mg BD
Tetracycline:
500 mg QID
Metronidazole:
400 mg TDS
Tinidazole:
500 mg BD
Regimens consist of two of the above antimicrobials taken along with a proton pump inhibitor for 1–3 weeks.
Anti-H. pylori kits (one kit to be taken daily in 2 doses)
HP-KIT, HELIBACT, OMXITIN:
Omeprazole 20 mg 2 cap + Amoxicillin 750 mg 2 tab + Tinidazole 500 mg 2 tab.
PYLOMOX:
Lansoprazole 15 mg 2 cap + Amoxicillin 750 mg 2 tab + Tinidazole 500 mg 2 tab.
LANSI KIT:
Lansoprazole 30 mg 1 cap + Amoxicillin 750 mg 1 tab + Tinidazole 500 mg 1 tab (one kit twice a day)
PYLOKIT, HELIGO:
Lansoprazole 30 mg 2 cap + Clarithromycin 250 mg 2 cap + Tinidazole 500 mg 2 tab.
LANPRO AC:
Lansoprazole 30 mg 2 cap + Clarithromycin 250 mg 2 tab + Amoxicillin 750 mg 2 tab.
Drugs for Peptic Ulcer
Gastric acid secretion inhibitors
(a) H2 antihistamines
Cimetidine, Ranitidine, Famotidine, Roxatidine
(b) Proton pump inhibitors
Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, S (-) Pantoprazole, Rabeprazole, Dexrabeprazole.
(c) Anticholinergics
Pirenzepine, Propantheline, Oxyphenonium
(d) Prostaglandin analogues
Misoprostol
Gastric acid neutralizers (Antacids)
(a) Systemic:
Sodium bicarbonate, Sod. citrate
(b) Nonsystemic:
Magnesium hydroxide, Mag. trisilicate, Aluminium hydroxide gel, Magaldrate, Calcium carbonate
Ulcer protectives
Sucralfate, Colloidal bismuth subcitrate (CBS)
Anti-H. pylori drugs
Amoxicillin, Clarithromycin, Metronidazole, Tinidazole, Tetracycline