Cholinergic Drugs


Cholinergic Agonists

Cholinomimetic – Parasympathomimetic

Choline esters

  • Acetylcholine
  • Methacholine
  • Carbachol
  • Bethanechol

Alkaloids

  • Muscarine
  • Pilocarpine
  • Arecoline

Anticholinesterases – Reversible

Carbamates

  • Physostigmine (Eserine)
  • Neostigmine
  • Pyridostigmine
  • Edrophonium
  • Rivastigmine, Donepezil
  • Galantamine

Acridine

  • Tacrine

Anticholinesterases – Irreversible

Organophosphates

  • Dyflos (DFP)
  • Echothiophate
  • Malathion – (Insecticides)
  • Diazinon (TIK-20) – (Insecticides)
  • Tabun, Sarin, Soman – (Nerve gases)

Carbamates

  • Carbaryl (SEVIN) – (Insecticides)
  • Propoxur (BAYGON) – (Insecticides)

Cholinergic Agonists Preparations

Bethanechol

10–40 mg Oral,
2.5–5 mg S.C.

Urotonin, Bethacol 25 mg Tab.


Pilocarpine

0.5–4% Topically In Eye.

Pilocar 1%, 2%, 4% Eye Drops
Carpine 0.5% Eye Drops
Pilodrops 2% Eye Drops.


Physostigmine

0.5–1.0 mg Oral/I.M.,
0.25–0.5% Topically In Eye.

Bi-Miotic 0.25% Eye Drops With 2% Pilocarpine Nitrate.


Neostigmine

15–30 mg Oral,
0.5–2.5 mg S.C./I.M.

Prostigmin, Myostigmin, Tilstigmin 15 mg Tab, 0.5 mg/Ml In 1 Ml And 5 Ml Inj.


Pyridostigmine

60–180 mg Oral.

Distinon, Myestin 60 mg Tab.


Rivastigmine

Initially 1.5 mg BD, Increase Every 2 Weeks By 1.5 mg/Day Upto 6 mg BD.

Exelon, Rivamer 1.5, 3, 4.5, 6.0 mg Caps.


Donepezil

5 mg At Bed Time Once Daily (Max 10 mg/Day).

Donecept, Dopezil, Dorent 5, 10 mg Tabs.


Galantamine

4 mg BD (Max 12 mg BD).

Galamer 4, 8, 12 mg Tabs.