Liver – Drugs Therapy

What is the Liver?

The liver is a large, reddish-brown organ inside our body that plays a big role in keeping us healthy.
It performs many essential tasks, like cleaning our blood or filtering blood, producing bile (which helps digest fats), storing energy and nutrients, protecting us from infections, and detoxifying harmful substances.
The liver performs over 500 functions, so think of it as a powerhouse that keeps many body functions running smoothly.

What is the Weight of the Liver?

The liver is one of the heaviest organs in our body. In an average adult, it weighs about 1.3 to 1.5 kilograms (or about 3 to 3.5 pounds).
Its size can vary a bit depending on a person’s body type, age, and overall health.
For adults, the weight typically ranges from 970 to 1,860 grams (2.14 to 4.10 pounds for men) and 600 to 1,770 grams (1.32 to 3.90 pounds for women).

Where is the Liver Located?

The liver is located in the upper right part of the abdominal cavity, just below the ribcage and below the lungs.
It sits above the stomach and right kidney, and is positioned under the diaphragm.
This location allows it to efficiently filter blood coming from the digestive organs before it circulates throughout the body.
If you place your right hand on your ribs, that’s roughly where your liver is. It’s mostly on the right side but stretches a bit to the left.

Shape of the Liver

The liver has a unique shape. It’s often compared to a triangle or wedge.
It’s broader at the top and narrows down as it moves to the side.
It has a smooth surface and a slight curve that fits the shape of the body under the ribs.
This shape allows it to fit snugly under the ribcage and stay protected.
It consists of two main lobes: a larger right lobe and a smaller left lobe. The liver’s structure includes smaller lobes called lobules, which are essential for its various functions.

What does the liver do?

The liver is an essential organ that performs a lot of critical jobs to keep our body healthy. Here’s a simple breakdown of what the liver does:

1. Filters Blood

The liver acts like a filter for our blood. It cleans out toxins (harmful substances) that come from food, drinks, and even medicines we take, preventing them from harming the body.

2. Produces Bile for Digestion

Bile is a yellow-green fluid made by the liver that helps break down fats in our food. This makes it easier for our body to digest and absorb fats and fat-soluble vitamins (like vitamins A, D, E, and K).

3. Stores Energy

The liver stores extra sugar (glucose) as glycogen, which can be converted back into glucose when the body needs energy, like between meals or during exercise.

4. Makes Important Proteins

The liver produces proteins that are essential for blood clotting (to stop bleeding) and for carrying oxygen through the blood.

5. Regulates Blood Sugar and Cholesterol Levels

The liver helps keep blood sugar steady by either storing or releasing glucose. It also helps control the levels of cholesterol, a type of fat that is needed but can be harmful in high amounts.

6. Helps Fight Infections

The liver is part of the immune system and helps fight off infections by removing bacteria and toxins from the blood.

7. Stores Vitamins and Minerals

It stores vitamins (like A, D, E, K, and B12) and minerals (like iron and copper) and releases them when the body needs them.

8. Processes Hormones and Drugs

The liver breaks down medications and hormones after they’ve done their job, making sure they don’t stay too long in the body and cause harm.

In short, the liver is like a multitasking powerhouse for our body—cleaning our blood, helping us digest food, storing energy, and protecting us from infections. Without it, our bodies wouldn’t be able to function properly!

What conditions and disorders can affect the liver?

The liver is a hardworking organ that helps process food, detoxify the blood, and produce important chemicals needed for digestion and blood clotting. However, various conditions can affect it, leading to health issues. Here are some common liver conditions explained simply:

1. Hepatitis

What it is: Hepatitis means inflammation of the liver. It can be caused by viruses, like hepatitis A, B, and C, or by drinking too much alcohol.
Symptoms: Often includes tiredness, yellowing of the skin and eyes (jaundice), dark urine, and stomach pain.
Treatment: Depends on the type of hepatitis; vaccines prevent some types, while others are managed with antiviral medications and lifestyle changes.

2. Fatty Liver Disease

What it is: This condition happens when too much fat builds up in the liver. It’s often linked to obesity, diabetes, and high cholesterol.
Types: There are two types—nonalcoholic fatty liver disease (NAFLD), which isn’t related to alcohol, and alcoholic fatty liver disease, which is due to excessive drinking.
Symptoms: Many people don’t have symptoms at first, but it can lead to liver damage over time.
Treatment: Losing weight, eating a balanced diet, and controlling blood sugar can help prevent and reverse fatty liver.

3. Cirrhosis

What it is: Cirrhosis is advanced scarring of the liver due to long-term damage. Common causes include hepatitis, fatty liver disease, and alcohol abuse.
Symptoms: Fatigue, loss of appetite, yellowing of the skin, and swelling in the legs and abdomen.
Treatment: There’s no cure, but the progression can be slowed by treating the underlying cause, like stopping alcohol or treating hepatitis.

4. Liver Cancer

What it is: Cancer that begins in the liver cells is called primary liver cancer. The most common type is hepatocellular carcinoma (HCC).
Causes: Chronic hepatitis B and C, cirrhosis, and long-term fatty liver disease increase the risk.
Symptoms: Weight loss, loss of appetite, nausea, pain, and swelling in the liver area.
Treatment: Options include surgery, chemotherapy, and sometimes liver transplants.

5. Liver Failure

What it is: Liver failure happens when the liver loses its ability to function, often due to long-term liver diseases or a sudden injury, like overdose on certain medications (e.g., acetaminophen).
Symptoms: Jaundice, confusion, bleeding easily, and extreme fatigue.
Treatment: In severe cases, a liver transplant is needed.

6. Autoimmune Hepatitis

What it is: A condition where the immune system attacks liver cells, causing inflammation.
Symptoms: Fatigue, joint pain, yellowing of the skin, and abdominal pain.
Treatment: Immunosuppressive medications to reduce immune system activity.

7. Hemochromatosis

What it is: A genetic disorder where the body absorbs too much iron, which then builds up in the liver, heart, and other organs.
Symptoms: Joint pain, fatigue, and a bronze or grayish color to the skin.
Treatment: Removing blood from the body regularly to reduce iron levels.

8. Primary Biliary Cholangitis (PBC)

What it is: A chronic disease where the bile ducts in the liver are slowly destroyed, which can lead to liver damage over time.
Symptoms: Fatigue, itching, dry eyes and mouth, and jaundice.
Treatment: Medications to slow liver damage, and in severe cases, a liver transplant.

9. Wilson’s Disease

What it is: A rare genetic disorder where copper builds up in the liver and other organs.
Symptoms: Fatigue, jaundice, and sometimes neurological symptoms like tremors or trouble speaking.
Treatment: Medications to reduce copper levels and dietary adjustments.

10. Gallstones

What it is: Gallstones are hard deposits that can form in the gallbladder and may block bile flow, affecting the liver.
Symptoms: Pain in the upper right side of the abdomen, nausea, and vomiting.
Treatment: Sometimes gallbladder removal is needed if gallstones cause frequent issues.

Each liver condition is different, but early detection, lifestyle changes, and appropriate treatment can help manage or even reverse some of these problems.

How to keep the liver healthy?

Keeping your liver healthy is important because it helps the body get rid of toxins, stores energy, and plays a key role in digestion. Here are some simple, practical tips that anyone can follow for a healthy liver:

1. Eat a Balanced Diet

More Fruits & Veggies: They’re full of fiber and vitamins. Apples, oranges, spinach, and carrots are all good options.
Go Easy on Fatty Foods: Avoid fried foods, fast food, and processed snacks. Choose lean meats, fish, nuts, and healthy fats like olive oil.
Choose Whole Grains: Foods like brown rice, oats, and whole wheat bread help with digestion and are gentler on the liver.

2. Limit Alcohol Intake

Too much alcohol can damage liver cells, leading to liver disease over time.
If you drink, stick to moderation: no more than one drink per day for women and two for men.

3. Stay Hydrated

Drinking plenty of water helps the liver flush out toxins.
Aim for 8-10 glasses of water daily.

4. Avoid Toxins

Limit exposure to harmful chemicals like insect sprays, cleaning products, and certain paints.
If you must use them, ensure good ventilation and wear protective gear.

5. Maintain a Healthy Weight

Extra weight increases the risk of fatty liver disease, which can lead to liver damage.
Regular physical activity and a healthy diet can help with weight management.

6. Exercise Regularly

Exercise helps reduce liver fat and improves overall health.
Aim for at least 30 minutes of exercise, like walking, biking, or swimming, most days of the week.

7. Limit Sugar and Processed Foods

High-sugar foods and sugary drinks increase fat build-up in the liver.
Choose natural sugars from fruits and avoid processed foods with added sugars.

8. Be Cautious with Medications and Supplements

Some medicines, including painkillers like acetaminophen, can harm the liver if taken in excess.
Always follow the recommended dosage and talk to a doctor before mixing medications or taking new supplements.

9. Get Vaccinated

Hepatitis A and B are viruses that can damage the liver. Vaccines are available for both.
Consider getting vaccinated, especially if you’re at higher risk.

10. Regular Health Checkups

Routine blood tests can help monitor liver health.
If you have a family history of liver issues or certain lifestyle risks, talk to a doctor about regular liver check-ups.

So, eat healthy, stay active, avoid alcohol and toxins, drink water, and keep up with regular check-ups. Taking care of your liver keeps your whole body healthier and more energetic!